9:00-10:00

Registration & Coffee

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10:00-10:15

Opening remarks - Welcome note

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10:15-10:55

Session 1. Protein homeostasis 1
Chair: Ellen Nollen

• 10:15-10:40
  Speakers: Alessandro Ori, Genentech, South San Francisco, USA / Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Jena, Germany
  The aging brain proteome of a short-lived vertebrate

• 10:40-10:55
  ​Milos Filipovic, Leibniz Institute for Analytical Sciences, ISAS, Berlin, Germany
  Age-induced thiol oxidation predisposes brain for neurodegeneration via aberrant phase separation

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10:55-11:30

Coffee-break

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11:30-12:25

Session 1. Protein homeostasis 2

Chair: Ellen Nollen

• 11:30-11:55
  Malene Hansen, The Buck Institute, Novato, USA
  Regulation of autophagy in aging and disease

• 11:55-12:10​
  Paola Gallardo, ERIBA-UMCG, Groningen, The Netherlands
  Poor old Pores: Surveillance of intrinsically disordered nucleoporins

• 12:10-12:25​
  Janine Kirstein, Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Jena, Germany
  The role of chaperones in the phase-separation of Huntingtin

 

12:25-13:25

Lunch

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13:25-14:45
Chair: Cor Calkhoven

Session 2: Metabolism

• 13:25-13:50
  Dudley Lamming, University of Wisconsin-Madison, USA
  When a calorie is not just a calorie: The regulation of health and longevity by dietary macronutrients

• 13:50-14:15
  Peter Tessarz, Max Planck Institute for Biology of Ageing, Cologne, Germany
  Metabolism-epigenetics crosstalk in ageing

• 14:-15-14:30
  ​Sanne Van der Rijt, Amsterdam UMC, The Netherlands
  Targeting phospholipid metabolism via Pla2g15 results in reduced senescence in murine kidney and increases longevity in C. elegans

• 14:30-14:45
  Friedrich Becker, Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Jena, Germany
  Dietary vitamin A restriction rescues declines in liver fat metabolism and ameliorates sarcopenia in aging mice 

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14:45-15:15

Coffee-break

15:15-16:10
Chair: Folkert Kuipers
Session 3: Gut microbiome

• 15:15-15:40
  Sasha Zhernakova, University Medical Center Groningen, The Netherlands
  Biological aging markers in population cohorts - microbiome and more.

• 15:40-15:55
  Aki Minoda, RIMLS, Radboud University Nijmegen, The Netherlands
  Mu-kin Mouse Ageing Atlas: How the microbiota affect ageing

• 15:55-16:10
  Dennis De Bakker, Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Jena, Germany 
  Microbiota transplantation can mitigate age-related brain inflammation and functional decline in a model of spontaneous Alzheimer’s-like pathology

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16:10-18:00

Poster Session

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18:00-18:45

Dinner at UMCG Fontein Patio

 

18:45-19:30

Keynote Lecture
Introduction: Cor Calkhoven

Michael Hall, Biozentrum, University of Basel, Switzerland
mTOR signaling in growth and metabolism

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20:00-22:00

Reception at the City Hall invited by the Mayor of Groningen

9:00-10:20

Session 4. Senescence

Chair: Tamar Tchkonia

• 9:00-9:25
  Marco Demaria, ERIBA-UMCG, Groningen, The Netherlands
  Purinergic signalling reinforces the production of SASP factors and promotes senescence-associated dysfunctions

• 9:25-9:50
  Raffaella di Micco, I.R.C.C.S. Ospedale San Raffaele, Milano, Italy
  Exploiting senescence immunogenicity for leukemia treatment

• 9:50-10:05​
  Akiko Mammoto, Medical College of Wisconsin, USA
  Endothelial senescence in hypoxia-induced lung vascular remodeling

• 10:05-10:20
  Boshi Wang, ERIBA-UMCG, Groningen, The Netherlands
  Sex dimorphism in senescent cell turnover is mediated by FABP5
   

10:20-10:50

Coffee break

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10:50-12:10
Session 5. Immune ageing
Chair: Claudia Waskow

• 10:50-11:15
  Vishwa Deep Dixit, Yale School of Medicine, New Haven, USA
  Metabolic control of inflammaging

• 11:15-11:40
  Mihai Netea, Radboud MC, Nijmegen, the Netherlands/ Limes, University of Bonn, Germany
  Impact of aging on trained immunity

• 11:40-11:55
  ​Enric Urena Sala, University College London, UK
  Exploring the mechanisms of action of the life-extending drug trametinib in Drosophila

• 11:55-12:10
  Patrick Schädel, Friedrich Schiller University, Jena, Germany
  Oxylipins as novel biomarkers of cellular and organismal inflammaging

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12:10-13:30

Lunch and meet with the speakers (PhD students and Postdoc career advise)

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13:30-14:50

Session 6. Stem cells and regeneration

Chair: Björn von Eyss

• 13:30-13:55
  Maximina Yun, Center for Regenerative Therapies TU Dresden, Germany
  Towards uncovering the basis of negligible senescence in vertebrates: enter the salamander

• 13:55-14:20
  Julia von Maltzahn, B-TU Cottbus-Senftenberg, Germany
  Muscle stem cells in age and disease

• 14:20-14:35​
  Alberto Minetti, Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Jena, Germany
  Proteostasis stress delays regeneration following injury in old small intestine epithelium 

• 14:35-14:50
  Hugo Fernandes, University of Coimbra, Portugal
  Unlocking the regenerative potential of extracellular vesicles: Bioactivity enhancement through miRNA modulation

 

14:50-15:20

Coffee break

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15:20-16:40

Session 7. DNA damage and genome regulation

Chair: Michael Chang

• 15:20-15:45
  George Garinis, University of Crete, Greece
  DNA damage and innate immune responses during aging

• 15:45-16:10
  Björn Schumacher, CECAD, University of Cologne, Germany
  Genome Stability in aging and inheritance: new insights from C. elegans

• 16:10-16:25
  Rouven Arnold, SBP Medical Discovery Institute, La Jolla, USA
  Unraveling protective mechanisms of aging: A new role for histone chaperone HIRA

• 16:25-16:40
  Mihailo Mirkovic, ETH, Zürich, Switzerland
  Introns drive asymmetric chromosome inheritance in ageing

 

16:40-17:25

Keynote Lecture
Introduction: Helen Morrison

Linda Partridge, UCL, London, UK
Ageing: a gut feeling

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18:00-00:00

Dinner and party at the DOT – 10th anniversary ERIBA – B-flat Carpet Jazz Quintet – DJ – The Blues Cowboys

9:30-10:10
Session 8. Organismal aging

Chair: Eugene Berezikov

• 9:30-9:55
  Thomas Bosch, Christian Albrechts University of Kiel, Germany
  Longevity, cellular senescence and the microbiome - lessons from the non-senescent model Hydra

• 9:55-10:10
  Johannes Krug, Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Jena, Germany 
  The transparent klara line as a tool for in vivo analyses

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10:10-10:40
Socioeconomic aspects of health and lifespan extension therapies Introduction: Ellen Nollen
Jochen Mierau, Lifelines, University of Groningen, The Netherlands

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10:40-11:00
Coffee break

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11:00-11:45

Keynote Lecture
Introduction: Folkert Kuipers

James (Jim) Kirkland, Mayo Clinic, Rochester, USA
Clinical studies of agents targeting aging mechanisms: the Translational Geroscience Network

11:45-12:15

Closure

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12:15

Lunch